2024cacib-apsot

*Keynote Speakers*

**Yu-Ju, Chen**
Professor & Research fellow
Academia Sinica
**Title : Nanoscale-to-Single Cell Proteomics by Chip-DIA Mass Spectrometry**

Dr. Chen obtained her B.S. in chemistry from National Taiwan University (1992) and Ph.D. degree from Iowa State University (1997). After postdoctoral research work at the Ames Laboratory, Department of Energy, USA [1997] and National Tsing Hua University [1999], Dr. Chen joined the Institute of Chemistry of Academia Sinica and was promoted to research fellow (2010). Since 2013, she has been the Director for the Institute of Chemistry at Academia Sinica. She also currently holds con-current adjunct professorships at few universities.

Her research focuses on methodology development of mass spectrometry-based proteomics by integrating novel nanomaterial, advanced mass spectrometry and bioinformatics. In particular, she is interested in applying these tools to delineate the membrane proteome and post-translation modificome on cancer and stem cell biology. She has received domestic and international awards including Outstanding Young Investigator Award from Chinese Chemical Society (2006), Distinguished Young Chemists Award from Federation of Asian Chemical Societies (2007), Mr. Wu Ta-you Memorial Award from National Science Council (2008), and Research Award for Junior Research Investigators from Academia Sinica (2008), the first award for outstanding scholar of Taiwan Society for Mass Spectrometry (2011), outstanding young scholar, 13th Shu-Mu Foundation of Chemistry (2012), and the outstanding research award from National Science Council (2013). She has been the Executive Committee Member of Human Proteome Organization (HUPO), Council Member of “Asia Oceana Human Proteome Organization” and “International Mass Spectrometry Foundation”. She has been the President of the Taiwan Proteomics Society, President of Taiwan Society for Mass Spectrometry.

Dr. Chen served as president for the Human Proteome Organization (2021-2022), the Taiwan Proteomics Society, and the Taiwan Society for Mass Spectrometry (2012-2015). She has been a council member of the Asia Oceania Human Proteome Organization since 2019. She current serves as executive director of the Taiwan Proteomics Society (2021-2023), and the Taiwan Society for Mass Spectrometry. She served on editorial boards of European Journal of Mass Spectrometry, Journal of Proteome Research, and Frontiers in Analytical Chemistry, and currently serves on the Executive Advisory Board of Proteomics.



**Xiaowei Zhuang**
Howard Hughes Medical Institute Investigator
David B. Arnold Jr. Professor of Science
Professor of Chemistry and Chemical Biology
Professor of Physics
Harvard University
**Title : Spatially resolved single-cell genomics & cell atlas of the brain**

Xiaowei is a professor of Science, Chemistry and Chemical Biology, and Physics at Harvard University and an Investigator at HHMI. Xiaowei’s lab is known for the development of both MERFISH and STORM for super resolution microscopy. She has won numerous awards including the 2021 Lurie Prize in Biomedical Sciences, 2019 Breakthrough Prize in Life Sciences and the 2019 NAS Award for Scientific Discovery. Xiaowei has been elected to both the National Academy of Sciences and National Academy of Medicine.



**Katsuhiko Shirahige**
Professor,
The University of Tokyo
**Title : Basic principles of transcription studied through rare diseases**

On chromosomes, multiple DNA-protein interactions are coordinated into networks, which play essential roles in controlling chromosome shape and ensuring the proper execution of various activities on DNA. Prof. Shirahige has significantly contributed to establishing this concept by introducing genomic approaches to the chromosome biology field. His early studies of replication profiles of budding yeast chromosome VI (Mol. Cell. Biol. 1993, Nature 1998) showed that an intra-S-phase checkpoint controls replication origin firing. This finding led to his design and development of high-resolution whole-genome tiling arrays to analyze precise protein localization along chromosomes (the technique now famously known as ChIP-chip analysis). Using this technology, he showed that mediators of the intra-S-phase checkpoint are parts of replication machinery (Nature 2003). By applying the same technique to the analysis of human chromosomes, he discovered that cohesin, an essential protein complex for chromosome segregation, plays another important role in transcriptional regulation as an insulator (Nature 2008). With the advent of next generation sequencing, he demonstrated that genomic approaches are powerful also in elucidating the molecular mechanisms of common and rare genetic diseases associated with altered chromatin structure. This revealed an unexpected link between cohesin and the transcription elongation machinery (Nature 2012, Nature Genetics 2015, Nature Commun. 2015, JEM 2017, Current Biol. 2015, 2018, Cancer Discovery 2020, Nature Commun. 2022, 2023, Science Adv. 2022, Mol. Cell 2024). Prof. Shirahige’s findings and technologies have greatly impacted the fields of chromosome biology, genome biology, and medicine. His countless fruitful international collaborations testify to these methods' tremendous impact.
Besides his scientific achievement, he has been appointed as professor and director of IQB at the Univ. of Tokyo since 2018. He was recently appointed as a PI and visiting professor at Karolinska Institutet.



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Important Dates

Abstract Submission Opens:
1 January 2024

Abstract Submission Deadline:
End of April 2024

Abstract Notifications*:
Early May, 2024

Registration Before:
23 May 2024

Conference date:
23-25 May 2024


	Yu-Ju, Chen Professor & Research fellow Academia Sinica Title : Nanoscale-to-Single Cell Proteomics by Chip-DIA Mass Spectrometry
	Dr. Chen obtained her B.S. in chemistry from National Taiwan University (1992) and Ph.D. degree from Iowa State University (1997). After postdoctoral research work at the Ames Laboratory, Department of Energy, USA [1997] and National Tsing Hua University [1999], Dr. Chen joined the Institute of Chemistry of Academia Sinica and was promoted to research fellow (2010). Since 2013, she has been the Director for the Institute of Chemistry at Academia Sinica. She also currently holds con-current adjunct professorships at few universities. Her research focuses on methodology development of mass spectrometry-based proteomics by integrating novel nanomaterial, advanced mass spectrometry and bioinformatics. In particular, she is interested in applying these tools to delineate the membrane proteome and post-translation modificome on cancer and stem cell biology. She has received domestic and international awards including Outstanding Young Investigator Award from Chinese Chemical Society (2006), Distinguished Young Chemists Award from Federation of Asian Chemical Societies (2007), Mr. Wu Ta-you Memorial Award from National Science Council (2008), and Research Award for Junior Research Investigators from Academia Sinica (2008), the first award for outstanding scholar of Taiwan Society for Mass Spectrometry (2011), outstanding young scholar, 13th Shu-Mu Foundation of Chemistry (2012), and the outstanding research award from National Science Council (2013). She has been the Executive Committee Member of Human Proteome Organization (HUPO), Council Member of “Asia Oceana Human Proteome Organization” and “International Mass Spectrometry Foundation”. She has been the President of the Taiwan Proteomics Society, President of Taiwan Society for Mass Spectrometry. Dr. Chen served as president for the Human Proteome Organization (2021-2022), the Taiwan Proteomics Society, and the Taiwan Society for Mass Spectrometry (2012-2015). She has been a council member of the Asia Oceania Human Proteome Organization since 2019. She current serves as executive director of the Taiwan Proteomics Society (2021-2023), and the Taiwan Society for Mass Spectrometry. She served on editorial boards of European Journal of Mass Spectrometry, Journal of Proteome Research, and Frontiers in Analytical Chemistry, and currently serves on the Executive Advisory Board of Proteomics.


	Xiaowei Zhuang Howard Hughes Medical Institute Investigator David B. Arnold Jr. Professor of Science Professor of Chemistry and Chemical Biology Professor of Physics Harvard University Title : Spatially resolved single-cell genomics & cell atlas of the brain
	Xiaowei is a professor of Science, Chemistry and Chemical Biology, and Physics at Harvard University and an Investigator at HHMI. Xiaowei’s lab is known for the development of both MERFISH and STORM for super resolution microscopy. She has won numerous awards including the 2021 Lurie Prize in Biomedical Sciences, 2019 Breakthrough Prize in Life Sciences and the 2019 NAS Award for Scientific Discovery. Xiaowei has been elected to both the National Academy of Sciences and National Academy of Medicine.


	Katsuhiko Shirahige Professor, The University of Tokyo Title : Basic principles of transcription studied through rare diseases
	On chromosomes, multiple DNA-protein interactions are coordinated into networks, which play essential roles in controlling chromosome shape and ensuring the proper execution of various activities on DNA. Prof. Shirahige has significantly contributed to establishing this concept by introducing genomic approaches to the chromosome biology field. His early studies of replication profiles of budding yeast chromosome VI (Mol. Cell. Biol. 1993, Nature 1998) showed that an intra-S-phase checkpoint controls replication origin firing. This finding led to his design and development of high-resolution whole-genome tiling arrays to analyze precise protein localization along chromosomes (the technique now famously known as ChIP-chip analysis). Using this technology, he showed that mediators of the intra-S-phase checkpoint are parts of replication machinery (Nature 2003). By applying the same technique to the analysis of human chromosomes, he discovered that cohesin, an essential protein complex for chromosome segregation, plays another important role in transcriptional regulation as an insulator (Nature 2008). With the advent of next generation sequencing, he demonstrated that genomic approaches are powerful also in elucidating the molecular mechanisms of common and rare genetic diseases associated with altered chromatin structure. This revealed an unexpected link between cohesin and the transcription elongation machinery (Nature 2012, Nature Genetics 2015, Nature Commun. 2015, JEM 2017, Current Biol. 2015, 2018, Cancer Discovery 2020, Nature Commun. 2022, 2023, Science Adv. 2022, Mol. Cell 2024). Prof. Shirahige’s findings and technologies have greatly impacted the fields of chromosome biology, genome biology, and medicine. His countless fruitful international collaborations testify to these methods' tremendous impact. Besides his scientific achievement, he has been appointed as professor and director of IQB at the Univ. of Tokyo since 2018. He was recently appointed as a PI and visiting professor at Karolinska Institutet.

Keynote Speakers